Biological applications on a miniaturized pulsed extraction TOF mass spectrometer

Presented at the
2nd Workshop on Harsh-Environment Mass Spectrometry
March 18-21, 2001, St. Petersburg, Florida, Center for Ocean Technology

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 Author: M. C. Prieto
Johns Hopkins University, Baltimore
Table of Contents
  1. Title - Miniaturized pulsed extraction TOF
  2. Overview
  3. MS miniaturization - Prof. RJ Cotter’s laboratory
  4. How does MALDI work?
  5. How does MALDI work? II
  6. How does the TOF mass spectrometer work?
  7. TOF parameter has properties other than the ion mass
  8. How is mass measurement by TOF affected by the MALDI process ?
  9. How is mass measurement by TOF affected by the MALDI process ?
  10. How to correct for spatial/energy distributions
  11. What is pulsed-extraction with delay time? What can it achieve ?
  12. Miniaturized linear time-of-flight mass spectrometer
  13. Miniaturized linear time-of-flight mass spectrometer II
  14. Miniaturized linear time-of-flight mass spectrometer III
  15. Instrument photo/A>
  16. Not-too-harsh environment
  17. Mass spectrum of ACTH on the linear TOF mass spectrometer
  18. Mass spectrum of cytochrome C on the linear TOF mass spectrometer
  19. Instrument reproducibility cytochrome C
  20. Objectives
  21. Bacillus globigii spores
  22. Bacillus globigii spores II
  23. Immediate future
  24. Oligonucleotides by mass spectrometry
  25. Miniarture linear instrument
  26. Mixture of five oligonucleotide strands
  27. Oligonucleotides by mass spectrometry (Follow-up)
  28. Goal: Redesigned endcap reflectron TOF
  29. References
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